{"created":"2023-06-19T07:38:00.158286+00:00","id":983,"links":{},"metadata":{"_buckets":{"deposit":"821a8071-ee2c-4730-8884-0e040c749523"},"_deposit":{"created_by":3,"id":"983","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"983"},"status":"published"},"_oai":{"id":"oai:mdu.repo.nii.ac.jp:00000983","sets":["1:42:93"]},"author_link":["0"],"item_2_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Treatment of Arsenic Poisoning with DMSA or DMPS in the Rat"}]},"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1993-04-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"44","bibliographicPageStart":"40","bibliographicVolumeNumber":"19","bibliographic_titles":[{"bibliographic_title":"松本歯学"}]}]},"item_2_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Among many metal binding agents, 2, 3-dimercaptosuccinic acid (DMSA) and 2, 3 -dimercapto-1-propanesulfonic acid (DMPS) have been reported as effective antagonists against toxicity of several metals including arsenic. Rats appear to have a metabolic pathway different from that of mice in detoxicating arsenic in that rats accumulate arsenic in the blood (erythrocytes). Two experiments were carried out in order to determine the effects of DMSA and DMPS on the arsenic poisoned rats and to compare the results obtained with those of mice. In the first experiment, using arsenic poisoned rats, both DMSA and DMPS promoted the excretion of arsenic, in contrast to the results of mice previously reported in which those antidotes only accelerated the excretion of arsenic (Table 1). In the second experiment, both groups of rats and mice were given mixture of arsenic and DMSA or DMPS, respectively. The results showed that in mice 100% of dosed arsenic was excreted by DMPS within 48 hrs, while in rats 82% of the dose was eliminated by DMPS and about 20 % still remained within some of the tissues after 72 hrs (Tables 2, 3 and 4).","subitem_description_type":"Abstract"}]},"item_2_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"松本歯科大学学会"}]},"item_2_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00232590","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0385-1613","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"前橋, 浩"},{"creatorName":"村田, 由里子"},{"creatorName":"宮澤, 淑子"}],"nameIdentifiers":[{"nameIdentifier":"0","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2012-05-24"}],"displaytype":"detail","filename":"matsumoto_shigaku_19-01-07.pdf","filesize":[{"value":"315.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"matsumoto_shigaku_19-01-07.pdf","url":"https://mdu.repo.nii.ac.jp/record/983/files/matsumoto_shigaku_19-01-07.pdf"},"version_id":"e20f5e40-92bc-44fd-868b-054cd0ab4267"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"有害金属拮抗薬","subitem_subject_scheme":"Other"},{"subitem_subject":"ラット","subitem_subject_scheme":"Other"},{"subitem_subject":"マウス","subitem_subject_scheme":"Other"},{"subitem_subject":"DMSA","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"DMPS","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"有害金属拮抗薬DMSAおよびDMPSによるヒ素の排泄効果 : ラットとマウスの比較","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"有害金属拮抗薬DMSAおよびDMPSによるヒ素の排泄効果 : ラットとマウスの比較"}]},"item_type_id":"2","owner":"3","path":["93"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-05-24"},"publish_date":"2012-05-24","publish_status":"0","recid":"983","relation_version_is_last":true,"title":["有害金属拮抗薬DMSAおよびDMPSによるヒ素の排泄効果 : ラットとマウスの比較"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-19T08:25:15.444764+00:00"}