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  1. 学位論文
  2. 2016

Migration and Differentiation of GFP-transplanted Bone Marrow-derived Cells into Experimentally Induced Periodontal Polyp in Mice

https://mdu.repo.nii.ac.jp/records/2664
https://mdu.repo.nii.ac.jp/records/2664
b1cbf4d9-b7c6-4c26-8c12-075f26a84788
名前 / ファイル ライセンス アクション
33602_A000233_honbun.pdf 本文 (1.8 MB)
license.icon
33602_A000233_shinsa-yoshi.pdf 内容の要旨および審査の結果の要旨 (325.2 kB)
Item type 学位論文 / Thesis or Dissertation正(1)
公開日 2017-05-15
タイトル
タイトル Migration and Differentiation of GFP-transplanted Bone Marrow-derived Cells into Experimentally Induced Periodontal Polyp in Mice
言語 en
言語
言語 eng
キーワード
言語 en
主題Scheme Other
主題 Periodontal polyp
キーワード
言語 en
主題Scheme Other
主題 Periodontal ligament
キーワード
言語 en
主題Scheme Other
主題 Cell differentiation
キーワード
言語 en
主題Scheme Other
主題 Immunohistochemistry
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_db06
資源タイプ doctoral thesis
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
その他(別言語等)のタイトル
その他のタイトル マウスにおける実験的に発生させた歯根膜ポリープへのGFP移植骨髄由来細胞の移動と分化
著者 MATSUDA, SAEKA

× MATSUDA, SAEKA

MATSUDA, SAEKA

SHOMURA, MASAHITO

× SHOMURA, MASAHITO

SHOMURA, MASAHITO

OSUGA, NAOTO

× OSUGA, NAOTO

OSUGA, NAOTO

TSUJIGIWA, HIDETSUGU

× TSUJIGIWA, HIDETSUGU

TSUJIGIWA, HIDETSUGU

NAKANO, KEISUKE

× NAKANO, KEISUKE

NAKANO, KEISUKE

OKAFUJI, NORIMASA

× OKAFUJI, NORIMASA

OKAFUJI, NORIMASA

OCHIAI, TAKANAGA

× OCHIAI, TAKANAGA

OCHIAI, TAKANAGA

HASEGAWA, HIROMASA

× HASEGAWA, HIROMASA

HASEGAWA, HIROMASA

KAWAKAMI, TOSHIYUKI

× KAWAKAMI, TOSHIYUKI

KAWAKAMI, TOSHIYUKI

著者別名 松田, 紗衣佳

× 松田, 紗衣佳

松田, 紗衣佳

抄録
内容記述タイプ Abstract
内容記述 Perforation of floor of the dental pulp is often encountered during root canal treatment in routine clinical practice of dental caries. If perforation were large, granulation tissue would grow to form periodontal polyp. Granulation tissue consists of proliferating cells however their origin is not clear. It was shown that the cells in granulation tissue are mainly from migration of undifferentiated mesenchymal cells of the bone marrow. Hence, this study utilized GFP bone marrow transplantation mouse model. The floor of the pulp chamber in maxillary first molar was perforated using ½ dental round bur. Morphological assessment was carried out by micro CT and microscopy and GFP cell mechanism was further assessed by immunohistochemistry using double fluorescent staining with GFP-S100A4; GFP-Runx2 and GFP-CD31. Results of micro CT revealed alveolar bone resorption and widening of periodontal ligament. Histopathological examination showed proliferation of fibroblasts with some round cells and blood vessels in the granulation tissue. At 2 weeks, the outermost layer of the granulation tissue was lined by squamous cells with distinct intercellular bridges. At 4 weeks, the granulation tissue became larger than the perforation and the outermost layer was lined by relatively typical stratified squamous epithelium. Double immunofluorescent staining of GFP and Runx2 revealed that both proteins were expressed in spindle-shaped cells. Double immunofluorescent staining of GFP and CD31 revealed that both proteins were expressed in vascular endothelial cells in morphologically distinct vessels. The results suggest that fibroblasts, periodontal ligament fibroblasts and blood vessels in granulation tissue were derived from transplanted-bone marrow cells. Thus, essential growth of granulation tissue in periodontal polyp was caused by the migration of undifferentiated mesenchymal cells derived from bone marrow, which differentiated into fibroblasts and later on differentiated into other cells in response to injury.
書誌情報 en : International Journal of Medical Sciences

巻 13, 号 7, p. 500-506, 発行日 2016-06-29
情報源
関連名称 雑誌掲載論文(電子版)
ISSN
収録物識別子タイプ ISSN
収録物識別子 1449-1907
権利
権利情報 Copyright: 2016 © Ivyspring International Publisher. This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.
関連サイト
識別子タイプ URI
関連識別子 http://www.medsci.org/v13p0500.htm
関連名称 Ivyspring International Publisher
PubMed番号
識別子タイプ PMID
関連識別子 info:pmid/27429586
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.7150/ijms.15671
関連名称 info:doi/10.7150/ijms.15671
フォーマット
内容記述タイプ Other
内容記述 application/pdf
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
学位授与年度
内容記述タイプ Other
内容記述 2016
報告番号
内容記述タイプ Other
内容記述 甲第202号
学位授与番号
学位授与番号 甲第202号
学位授与年月日
学位授与年月日 2017-02-09
学位名
学位名 博士(歯学)
学位授与大学
学位授与機関名 松本歯科大学
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