Bone is an actively metabolized tissue. Bone volume is maintained through a balance of bone formation by osteoblasts and bone resorption by osteoclasts. Recent research demon-strated that receptor activator of NF-kB (RANK)-RANK ligand (RANKL) mechanism plays a pivotal role in the differentiating and activating osteoclasts. Osteoblast-lineage cells, consisting of osteoblasts, osteocytes and bone lining cells, regulate bone resorption via the expression of RANKL. The balance of RANKL and OPG, a decoy receptor for RANKL, is thought to regulate the bone remodeling. Thus, bone remodeling is accomplished by the harmonized interaction between osteoblast-lineage cells and osteoclasts. RANK-RANKL mechanism is also engaged in pathological bone resorption such as periodontal diseases. New approach based on the interaction between osteoblasts and osteoclasts will be neces-sary to prevent and treat bone diseases.
骨代謝における骨芽細胞と破骨細胞の細胞連関
matsumoto_shigaku_31-02-01.pdf
(2.09MB)
