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破骨細胞の神秘
https://mdu.repo.nii.ac.jp/records/559
https://mdu.repo.nii.ac.jp/records/559cf01b007-6b0b-4f2e-ae16-df662a0ebc3f
名前 / ファイル | ライセンス | アクション |
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matsumoto_shigaku_30-01-02.pdf (2.5 MB)
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Item type | Journal Article(1) | |||||
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公開日 | 2012-05-24 | |||||
タイトル | ||||||
タイトル | 破骨細胞の神秘 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 骨化謝共役 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 破骨細胞 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 骨芽細胞 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | OPG | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 大理石骨病 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
その他(別言語等)のタイトル | ||||||
その他のタイトル | Mystery of osteoclasts | |||||
著者 |
中村, 美どり
× 中村, 美どり |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Deficiency of osteoprotegerin (OPG), a soluble decoy receptor for the receptor activator of NF-kB ligand (RANKL), in mice induces osteoporosis caused by enhanced bone resorption, but also accelerates bone formation. We examined whether bone formation is coupled with bone resorption in OPG-deficient (OPG^<-/->) mice delete using risedronate, an inhibitor of bone resorption. Histomorphometric analysis showed that bone formation-related parameters (e.g., mineral apposition rate and osteoblast surface/bone surface) in OPG^<-/-> mice sharply decreased with suppression of bone resorption by daily injection of risedronate for 30 days. OPG^<-/-> mice exhibited high serum alkaline phosphatase activity and osteocalcin concentration, both of which were decreased to the levels of wild-type mice by the risedronate injection. Serum levels of RANKL were markedly elevated in the OPG^<-/-> mice, but were unaffected by risedronate. These results suggest that bone formation is coupled with bone resorption at local sites in OPG^<-/-> mice, and that serum RANKL levels do not reflect this coupling. | |||||
書誌情報 |
松本歯学 巻 30, 号 1, p. 9-19, 発行日 2004-04-30 |
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出版者 | ||||||
出版者 | 松本歯科大学学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0385-1613 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00232590 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |