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Notch as a Possible Cell Differentiation Factor in Pleomorphic Adenomas
https://mdu.repo.nii.ac.jp/records/2513
https://mdu.repo.nii.ac.jp/records/25136dff7ff7-dc8e-4191-a35f-31ef19397e87
| 名前 / ファイル | ライセンス | アクション |
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本文 (1.0 MB)
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学位論文審査の結果及び最終試験の結果の要旨 (265.5 kB)
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| Item type | 学位論文 / Thesis or Dissertation正(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-06-15 | |||||
| タイトル | ||||||
| タイトル | Notch as a Possible Cell Differentiation Factor in Pleomorphic Adenomas | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Notch1 | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | pleomorphic adenoma | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | cell differentiation | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | immunohistochemistry | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| その他（別言語等）のタイトル | ||||||
| その他のタイトル | 多形腺腫における細胞分化因子としてのNotchの可能性 | |||||
| 著者 |
Takamine, Keisuke
× Takamine, Keisuke× Ueda, Yukiko× Nakano, Keisuke× Ochiai, Takanaga× Sugita, Yoshihiko× Kubo, Katsutoshi× Mada, Hatsuhiko× Hasegawa, Hiromasa× Kawakami, Toshiyuki |
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| 著者別名 |
高峰, 圭介
× 高峰, 圭介 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The expression of Notch in 30 cases of pleomorphic adenoma was examined by immunohistochemistry.Comparing the results of our study with previous literatures, from the partial CK7 expression and substantial Notch expression in ductal epithelial cells as well as the Notch expression in solid tumor nests, it can be inferred that Notch is involved in cell differentiation. CK13 expression was observed in cells undergoing squamous metaplasia and Notch expression was seen in the nucleus of basal and squamous cells. The intense Notch expression in basal cells and weak expression in squamous cells suggests that Notch is involved in the differentiation from basal to squamous cell. Moreover, the loss of nuclear expression on the inner layer would signify that differentiation is about to end or has been terminated. Notch was expressed in the cytoplasm of cartilage cells and in the cell membrane of mucous cells but not in the nucleus indicating that differentiation has been concluded. Notch involvement is suspected in cell differentiation in areas showing ductal structures and squamous metaplasia. In summary, Notch is involved in cell differentiation of ductal cells in PA. Nuclear expression was shown in tumor cells in solid nests and surrounding structures. Moreover, Notch is expressed by basal cells undergoing squamous metaplasia suggesting the participation of Notch in cell differentiation in PA. | |||||
| 書誌情報 |
en : International Journal of Medical Sciences 巻 12, 号 10, p. 759-763, 発行日 2015-09-05 |
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| 情報源 | ||||||
| 関連名称 | 雑誌掲載論文(電子版) | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1449-1907 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA1197928X | |||||
| 権利 | ||||||
| 権利情報 | © 2015 Ivyspring International Publisher. This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License.(https://creativecommons.org/licenses/by-nc/4.0/) | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.medsci.org/v12p0759.htm | |||||
| 関連名称 | Ivyspring International Publisher | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615235/ | |||||
| 関連名称 | PubMed Central® (PMC) | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | info:pmid/26516303 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.7150/ijms.12882 | |||||
| 関連名称 | info:doi/10.7150/ijms.12882 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 学位授与年度 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 2015 | |||||
| 報告番号 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 甲第183号 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲第183号 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2016-02-05 | |||||
| 学位名 | ||||||
| 学位名 | 博士（歯学） | |||||
| 学位授与大学 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 33602 | |||||
| 学位授与機関名 | 松本歯科大学 | |||||
