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Studies on Shokyo, Kanzo, and Keihi in Kakkonto Medicine on Prostaglandin E2 Production in Lipopolysaccharide-Treated Human Gingival Fibroblasts
https://mdu.repo.nii.ac.jp/records/2670
https://mdu.repo.nii.ac.jp/records/2670f70684e1-b3f0-4520-a667-7118a8f96f9c
| 名前 / ファイル | ライセンス | アクション |
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本文 (962.5 kB)
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| Item type | 松本歯学/学術雑誌論文 / Journal Article(1) | |||||||||
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| 公開日 | 2017-05-18 | |||||||||
| タイトル | ||||||||||
| タイトル | Studies on Shokyo, Kanzo, and Keihi in Kakkonto Medicine on Prostaglandin E2 Production in Lipopolysaccharide-Treated Human Gingival Fibroblasts | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| 著者 |
Ara, Toshiaki
× Ara, Toshiaki
× Sogawa, Norio
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| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | We previously demonstrated that a kampo medicine, kakkonto, decreases lipopolysaccharide- (LPS-) induced prostaglandin E2 (PGE2) production by human gingival fibroblasts. In this study, we examined the herbs constituting kakkonto that exhibit this effect. Shokyo strongly and concentration dependently and kanzo and keihi moderately decreased LPS-induced PGE2 production. Shokyo did not alter cyclooxygenase-2 (COX-2) activity, cytosolic phospholipaseA2 (cPLA2), annexin 1 and COX-2 expression, and LPS-induced extracellular signal-regulated kinase (ERK) phosphorylation. Kanzo inhibited COX-2 activity but increased annexin 1 and COX-2 expression and did not alter LPS-induced ERK phosphorylation. Keihi inhibited COX-2 activity and LPS-induced ERK phosphorylation but slightly increased COX-2 expression and did not alter cPLA2 and annexin 1 expression. These results suggest that the mechanism of shokyo is through the inhibition of cPLA2 activity, and that of kanzo and keihi is through the inhibition of COX-2 activity and indirect inhibition of cPLA2 activity.Therefore, it is possible that shokyo and kakkonto are clinically useful for the improvement of inflammatory responses. | |||||||||
| 書誌情報 |
en : International Scholarly Research Notices 巻 2016, 号 Article ID 9351787, 発行日 2016-10-13 |
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| 出版者 | Hindawi Publishing Corporation | |||||||||
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| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 2356-7872 | |||||||||
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| 関連タイプ | isIdenticalTo | |||||||||
| 識別子タイプ | PMID | |||||||||
| 関連識別子 | info:pmid/27819025 | |||||||||
| DOI | ||||||||||
| 関連タイプ | isIdenticalTo | |||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | http://dx.doi.org/10.1155/2016/9351787 | |||||||||
| 関連名称 | 10.1155/2016/935178 | |||||||||
| 権利 | ||||||||||
| 権利情報 | Copyright © 2016 T. Ara and N. Sogawa. This is an open access article distributed under the Creative Commons Attribution License(Attribution 4.0 International (CC BY 4.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |||||||||
| 情報源 | ||||||||||
| 関連名称 | 雑誌掲載論文(電子版) | |||||||||
| 関連サイト | ||||||||||
| 識別子タイプ | URI | |||||||||
| 関連識別子 | https://www.hindawi.com/journals/isrn/2016/9351787/ | |||||||||
| 関連名称 | Hindawi Limited | |||||||||
| 関連サイト | ||||||||||
| 識別子タイプ | URI | |||||||||
| 関連識別子 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081445/ | |||||||||
| 関連名称 | PubMed Central® (PMC) | |||||||||
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| 内容記述タイプ | Other | |||||||||
| 内容記述 | application/pdf | |||||||||
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| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
