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Comparableroles of CD44v8–10 and CD44s in the developmentof bone metastases in a mouse model.
https://mdu.repo.nii.ac.jp/records/2691
https://mdu.repo.nii.ac.jp/records/2691f777eaaa-4546-4a8e-80f2-5611a023471c
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
本文 (1.6 MB)
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| Item type | 松本歯学/学術雑誌論文 / Journal Article(1) | |||||||||
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| 公開日 | 2018-03-07 | |||||||||
| タイトル | ||||||||||
| タイトル | Comparableroles of CD44v8–10 and CD44s in the developmentof bone metastases in a mouse model. | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | CD44v8‑10 | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | CD44s | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | ESRP1 | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | bone metastases | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | cancer stem cells | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| 著者 |
HIRAGA, TORU
× HIRAGA, TORU
× NAKAMURA, HIROAKI
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| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Cluster of differentiation (CD)44 has been implicated in cancer metastasis to bone. Clinical and experimental studies have suggested that the standard isoform of CD44 (CD44s) and the variant isoform of CD44 (CD44v) enhance metastasis. The present study examined the differential roles of CD44s and CD44v, particularly CD44v8-10, in the development of bone metastases. For this purpose, MDA-MB-231 human breast cancer cells and A549 human lung cancer cells were stably transduced with epithelial splicing regulatory protein 1 (ESRP1), which regulates the alternative splicing of several genes, including CD44. The introduction of ESRP1 induced a splicing switch from CD44s to CD44v, particularly to CD44v8-10, while the total amount of CD44 was rarely affected. However, ESRP1 did not significantly affect cell proliferation, migration, invasion or tumor sphere formation in vitro. Furthermore, ESRP1 did not cause significant differences in the development of bone metastases in a mouse model. As an alternative approach, cancer cells transduced with the CD44v8-10 gene were also established. The overexpression of CD44v8-10 in MCF-7 human breast cancer cells, which rarely express any isoform of CD44, promoted cell migration and sphere formation, whereas the overexpression of CD44v8-10 in MDA-MB-231 cells, which endogenously express high levels of CD44s, did not exert these effects. The results of the present study collectively suggest that the ability of CD44v8-10 to promote tumor aggressiveness and bone metastases is similar to that of CD44s. CD44v8-10 and CD44s may represent potential therapeutic targets for the treatment of bone metastases. | |||||||||
| 書誌情報 |
en : Oncology letters 巻 12, 号 4, p. 2962-2969, 発行日 2016-08-10 |
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| 出版者 | ||||||||||
| 出版者 | Spandidos Publications | |||||||||
| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 1792-1082 | |||||||||
| PubMed番号 | ||||||||||
| 関連タイプ | isIdenticalTo | |||||||||
| 識別子タイプ | PMID | |||||||||
| 関連識別子 | info:pmid/27698884 | |||||||||
| DOI | ||||||||||
| 関連タイプ | isIdenticalTo | |||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | https://doi.org/10.3892/ol.2016.4985 | |||||||||
| 関連名称 | info:doi/10.3892/ol.2016.4985 | |||||||||
| 権利 | ||||||||||
| 権利情報 | © 2016 Hiraga, T et al. SPANDIDOS PUBLICATIONS UK LTD. Spandidos Publications makes articles freely available 12 month after the publication, | |||||||||
| 情報源 | ||||||||||
| 関連名称 | 雑誌掲載論文(電子版) | |||||||||
| 関連サイト | ||||||||||
| 識別子タイプ | URI | |||||||||
| 関連識別子 | https://www.spandidos-publications.com/ol/12/4/2962 | |||||||||
| 関連名称 | SPANDIDOS PUBLICATIONS UK LTD. | |||||||||
| 関連サイト | ||||||||||
| 識別子タイプ | URI | |||||||||
| 関連識別子 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038606/ | |||||||||
| 関連名称 | PUB MED CENTRAL | |||||||||
| フォーマット | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | application/pdf | |||||||||
| 著者版フラグ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
