| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2018-11-15 |
| タイトル |
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|
タイトル |
Periodontitis induced by bacterial infection exacerbates features of Alzheimer's disease in transgenic mice. |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Ishida, Naoyuki
Ishihara, Yuichi
Ishida, Kazuto
Tada, Hiroyuki
Funaki-Kato, Yoshiko
Hagiwara, Makoto
Ferdous, Taslima
Abdullah, Mohammad
Mitani, Akio
Michikawa, Makoto
Matsushita, Kenji
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Periodontitis is a localized infectious disease caused by periodontopathic bacteria,such as Porphyromonas gingivalis. Recently, it has been suggested that bacterial infections may contribute to the onset and the progression of Alzheimer’s disease (AD). However, we do not have any evidence about a causative relationship between periodontitis and AD. In this study, we investigated by using a transgenic mouse model of AD whether periodontitis evoked by P. gingivalis modulates the pathological features of AD. Cognitive function was significantly impaired in periodontitis-induced APP-Tg mice, compared to that in control APP-Tg mice. Levels of Amiloid β (Aβ) deposition, Aβ40, and Aβ42 in both the hippocampus and cortex were higher in inoculated APP-Tg mice than in control APP-Tg mice. Furthermore, levels of IL-1β and TNF-α in the brain were higher in inoculated mice than in control mice. The levels of LPS were increased in the serum and brain of P. gingivalis-inoculated mice. P. gingivalis LPS-induced production of Aβ40 and Aβ42 in neural cell cultures and strongly enhanced TNF-α and IL-1β production in a culture of microglial cells primed with Aβ. Periodontitis evoked by P. gingivalismay exacerbate brain Aβ deposition, leading to enhanced cognitive impairments, by a mechanism that involves triggering brain inflammation. |
| 書誌情報 |
en : NPJ aging and mechanisms of disease.
巻 6,
号 3,
p. 15,
発行日 2017-11-06
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| 出版者 |
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出版者 |
Nature Publishing Group, published in partnership with Japanese Society of Anti-Aging Medicine, |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
2056-3973 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1038/s41514-017-0015-x |
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関連名称 |
info:doi/10.1038/s41514-017-0015-x. |
| 権利 |
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|
権利情報 |
©2017 Author(s) Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| 情報源 |
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関連名称 |
雑誌掲載論文(電子版) |
| 関連サイト |
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識別子タイプ |
URI |
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関連識別子 |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673943/ |
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関連名称 |
PubMed Central® (PMC) |
| フォーマット |
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内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| 著者版フラグ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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