{"_buckets": {"deposit": "05a667b2-da9c-4f31-bba9-48eb8a6af3fb"}, "_deposit": {"created_by": 3, "id": "2747", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "2747"}, "status": "published"}, "_oai": {"id": "oai:mdu.repo.nii.ac.jp:00002747", "sets": ["237", "249", "268", "269", "373", "457", "459"]}, "author_link": ["4218", "4226", "4225", "4219", "4220", "4215", "4227", "4222", "4224", "4223", "4217", "4228", "4221", "4216"], "item_7_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2017-07-10", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageStart": "4928", "bibliographicVolumeNumber": "7", "bibliographic_titles": [{}, {"bibliographic_title": "Scientific reports.", "bibliographic_titleLang": "en"}]}]}, "item_7_creator_3": {"attribute_name": "著者別名", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Takahashi, Naoyuki"}], "nameIdentifiers": [{"nameIdentifier": "4227", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mizoguhci, Toshihide"}], "nameIdentifiers": [{"nameIdentifier": "4228", "nameIdentifierScheme": "WEKO"}]}]}, "item_7_description_19": {"attribute_name": "フォーマット", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_7_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Bone marrow mesenchymal stem and progenitor cells (BM-MSPCs) maintain homeostasis of bone tissue by providing osteoblasts. Although several markers have been identified for labeling of MSPCs, these labeled cells still contain non-BM-MSPC populations. Studies have suggested that MSPCs are observed as leptin receptor (LepR)-positive cells, whereas osteoblasts can be classified as positive for Runx2, a master regulator for osteoblastogenesis. Here, we demonstrate, using Runx2-GFP reporter mice,that the LepR-labeled population contains Runx2-GFPlow sub-population, which possesses higher fibroblastic colony-forming units (CFUs) and mesensphere capacity, criteria for assessing stem cell activity, than the Runx2-GFP− population. In response to parathyroid hormone (PTH), a bone anabolic hormone, LepR+Runx2-GFPlow cells increase Runx2 expression and form multilayered structures near the bone surface. Subsequently, the multilayered cells express Osterix and Type I collagen α, resulting in generation of mature osteoblasts. Therefore, our results indicate that Runx2 is weakly expressed in the LepR+ population without osteoblastic commitment, and the LepR+Runx2-GFPlow stromal cells sit atop the BM stromal hierarchy.", "subitem_description_type": "Abstract"}]}, "item_7_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Nature Publishing Group"}]}, "item_7_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "info:doi/10.1038/s41598-017-05401-1."}], "subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1038/s41598-017-05401-1", "subitem_relation_type_select": "DOI"}}]}, "item_7_relation_16": {"attribute_name": "情報源", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "雑誌掲載論文(電子版) "}]}]}, "item_7_relation_17": {"attribute_name": "関連サイト", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "PubMed Central® (PMC)"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503992/", "subitem_relation_type_select": "URI"}}, {"subitem_relation_name": [{"subitem_relation_name_text": "the publishers of Nature."}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://www.nature.com/articles/s41598-017-05401-1", "subitem_relation_type_select": "URI"}}]}, "item_7_rights_15": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© Mengyu Yang(et al) 2017 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/."}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "2045-2322", "subitem_source_identifier_type": "ISSN"}]}, "item_7_version_type_20": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Yang, Mengyu"}], "nameIdentifiers": [{"nameIdentifier": "4215", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Arai, Atsushi"}], "nameIdentifiers": [{"nameIdentifier": "4216", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Udagawa, Nobuyuki"}], "nameIdentifiers": [{"nameIdentifier": "4217", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hiraga, Toru"}], "nameIdentifiers": [{"nameIdentifier": "4218", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Lijuan, Zhao"}], "nameIdentifiers": [{"nameIdentifier": "4219", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ito, Susumu"}], "nameIdentifiers": [{"nameIdentifier": "4220", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Komori, Toshihisa"}], "nameIdentifiers": [{"nameIdentifier": "4221", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Moriishi, Takeshi"}], "nameIdentifiers": [{"nameIdentifier": "4222", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsuo, Koichi"}], "nameIdentifiers": [{"nameIdentifier": "4223", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shimoda, Kouji"}], "nameIdentifiers": [{"nameIdentifier": "4224", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Zahalka, Ali H"}], "nameIdentifiers": [{"nameIdentifier": "4225", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kobayashi, Yasuhiro"}], "nameIdentifiers": [{"nameIdentifier": "4226", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-11-15"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "2017-ja-007.pdf", "filesize": [{"value": "6.9 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_6", "mimetype": "application/pdf", "size": 6900000.0, "url": {"label": "本文", "url": "https://mdu.repo.nii.ac.jp/record/2747/files/2017-ja-007.pdf"}, "version_id": "8081f4f3-727b-49bd-9c1a-4173dfd13c05"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Osteogenic Factor Runx2 Marks a Subset of Leptin Receptor-Positive Cells that Sit Atop the Bone Marrow Stromal Cell Hierarchy", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Osteogenic Factor Runx2 Marks a Subset of Leptin Receptor-Positive Cells that Sit Atop the Bone Marrow Stromal Cell Hierarchy", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "3", "path": ["237", "249", "268", "269", "373", "457", "459"], "permalink_uri": "https://mdu.repo.nii.ac.jp/records/2747", "pubdate": {"attribute_name": "公開日", "attribute_value": "2018-11-15"}, "publish_date": "2018-11-15", "publish_status": "0", "recid": "2747", "relation": {}, "relation_version_is_last": true, "title": ["Osteogenic Factor Runx2 Marks a Subset of Leptin Receptor-Positive Cells that Sit Atop the Bone Marrow Stromal Cell Hierarchy"], "weko_shared_id": 3}