| Item type |
松本歯学/学術雑誌論文 / Journal Article(1) |
| 公開日 |
2018-11-15 |
| タイトル |
|
|
タイトル |
Neuron–Glia Crosstalk and Neuropathic Pain: Involvement in the Modulation of Motor Activity in the Orofacial Region |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
satellite glial cells |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
microglia |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
astroglia |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
neuropathic orofacial pain |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
orofacial motor activity |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Hossain, Mohammad Zakir
Unno, Shumpei
Ando, Hiroshi
Masuda, Yuji
Kitagawa, Junichi
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Neuropathic orofacial pain (NOP) is a debilitating condition. Although the pathophysiology remains unclear, accumulating evidence suggests the involvement of multiple mechanisms in the development of neuropathic pain. Recently, glial cells have been shown to play a key pathogenetic role. Nerve injury leads to an immune response near the site of injury. Satellite glial cells are activated in the peripheral ganglia. Various neural and immune mediators, released at the central terminals of primary afferents, lead to the sensitization of postsynaptic neurons and the activation of glia. The activated glia, in turn, release pro-inflammatory factors, further sensitizing the neurons, and resulting in central sensitization. Recently, we observed the involvement of glia in the alteration of orofacial motor activity in NOP. Microglia and astroglia were activated in the trigeminal sensory and motor nuclei, in parallel with altered motor functions and a decreased pain threshold. A microglial blocker attenuated the reduction in pain threshold, reduced the number of activated microglia, and restored motor activity. We also found an involvement of the astroglial glutamate–glutamine shuttle in the trigeminal motor nucleus in the alteration of the jaw reflex. Neuron–glia crosstalk thus plays an important role in the development of pain and altered motor activity in NOP. View Full-Text |
| 書誌情報 |
en : International Journal of Molecular Sciences
巻 18,
号 10,
p. e2051,
発行日 2017-09-26
|
| 出版者 |
|
|
出版者 |
MDPI |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1422-0067 |
| PubMed番号 |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
info:pmid/28954391 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.3390/ijms18102051 |
|
|
関連名称 |
info:doi/10.3390/ijma18102051 |
| 権利 |
|
|
権利情報 |
© 2017 Hossain MZ. et al © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
| 情報源 |
|
|
|
関連名称 |
雑誌掲載論文(電子版) |
| 関連サイト |
|
|
|
識別子タイプ |
URI |
|
|
関連識別子 |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666733/ |
|
|
関連名称 |
PubMed Central® (PMC) |
| 関連サイト |
|
|
|
識別子タイプ |
URI |
|
|
関連識別子 |
https://www.mdpi.com/1422-0067/18/10/2051 |
|
|
関連名称 |
IJMS Free Full-Text |
| フォーマット |
|
|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
本文 (2.7 MB)
.png)
