| Item type |
松本歯学/学術雑誌論文 / Journal Article(1) |
| 公開日 |
2019-05-15 |
| タイトル |
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タイトル |
Immunohistochemical expression of heat shock proteins in the mouse periodontal tissues due to orthodontic mechanical stress. |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Heat schock protein |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
HSP27 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
periodontal ligament calls |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
mechanical stress |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
orthodontic tooth movement |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Muraoka, R
Nakano, K
Kurihara, S
Yamada, K
Kawakami, T
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| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
The histopathology of periodontal ligament of the mouse subjected to mechanical stress was studied. Immunohistochemical expressions of HSP27 and p-HSP27 were examined. Experimental animals using the maxillary molars of ddY mouse by Waldo method were used in the study. A separator was inserted to induce mechanical stress. After 10 minutes, 20 minutes, 1 hour, 3 hours, 9 hours and 24 hours, the regional tissues were extracted, fixed in 4% paraformaldehyde and 0.05M phosphate-buffered fixative solution. Paraffin sections were made for immunohistochemistry using HSP27 and p-HSP27. In the control group, the periodontal ligament fibroblasts expressed low HSP27 and p-HSP27. However, in the experimental group, periodontal ligament fibroblasts expressed HSP27 10 minutes after mechanical load application in the tension side. The strongest expression was detected 9 hours after inducing mechanical load. p-HSP27 was also expressed in a time-dependent manner though weaker than HSP27. The findings suggest that HSP27 and p- HSP27 were expressed for the maintenance of homeostasis of periodontal ligament by the activation of periodontal ligament fibroblasts on the tension side. It also suggests that these proteins act as molecular chaperones for osteoblast activation and maintenance of homeostasis. |
| 書誌情報 |
en : European journal of medical research
巻 15,
号 11,
p. 475-482-482,
発行日 2010-11-25
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| 出版者 |
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出版者 |
I. Holzapfel(BioMed Central) |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
2047-783X |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA11331989 |
| PubMed番号 |
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関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
PMID |
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関連識別子 |
info:pmid/21159572 |
| DOI |
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|
関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.1186/2047-783X-15-11-475 |
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関連名称 |
info:doi/10.1186/2047-783X-15-11-475 |
| 権利 |
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|
権利情報 |
© I. Holzapfel Publishers 2010. licensed under the Creative Commons Attribution License 4.0. (https://creativecommons.org/licenses/by/4.0/legalcode) |
| 情報源 |
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関連名称 |
博士学位論文(2010年度松本歯科大学大学院歯学独立研究科) |
| 関連サイト |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.1186/2047-783X-15-11-475 |
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関連名称 |
BioMed Central |
| 関連サイト |
|
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|
識別子タイプ |
URI |
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|
関連識別子 |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352656/ |
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|
関連名称 |
PubMed Central |
| フォーマット |
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内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| 著者版フラグ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
本文 (7.0 MB)
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