{"_buckets": {"deposit": "8e5a9843-619c-45ed-b0ff-5be92a17422d"}, "_deposit": {"created_by": 3, "id": "2861", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "2861"}, "status": "published"}, "_oai": {"id": "oai:mdu.repo.nii.ac.jp:00002861", "sets": ["209", "499"]}, "author_link": ["4916", "4912", "4914", "4915", "4911", "4913"], "item_10001_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2018-09-13", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "11", "bibliographicPageEnd": "4730", "bibliographicPageStart": "4722-4730", "bibliographicVolumeNumber": "46", "bibliographic_titles": [{}, {"bibliographic_title": "The Journal of international medical research", "bibliographic_titleLang": "en"}]}]}, "item_10001_creator_3": {"attribute_name": "著者別名", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "島田, 勝光"}], "nameIdentifiers": [{"nameIdentifier": "4914", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "落合, 隆永"}], "nameIdentifiers": [{"nameIdentifier": "4915", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "長谷川, 博雅"}], "nameIdentifiers": [{"nameIdentifier": "4916", "nameIdentifierScheme": "WEKO"}]}]}, "item_10001_description_19": {"attribute_name": "フォーマット", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_10001_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Abstract Objective: Oral lichen planus (OLP) characterized by interface mucositis frequently shows hyper-keratinization. To clarify mechanisms of excess keratinization, we investigated key molecules for cornified cell envelope (CE). Methods: Involucrin (IVL), loricrin (LOR), transglutaminase 1 (TGase 1) and transglutaminase 3 (TGase 3) were immunohistochemically examined in 20 specimens of OLP; five specimens of buccal mucosa served as controls. Subsequently, the data were statistically analyzed. Results: IVL in OLP was localized in the cell membrane, in contrast to its localization in the cytoplasm in controls. No positive reaction indicative of LOR was noted in any specimens. Although the TGase 1 localization in controls was restricted to the upper three-quarters of the membrane, the localization in OLP was in both membrane and in the cytoplasm of full thickness mucosal layers. The TGase 3 localization pattern was dramatically altered from cytoplasmic to membranous in OLP. Conclusion: Our data suggest that aberrant TGase 1 and TGase 3 localization and distribution are closely related to hyper-keratinization in OLP. This is the first report of ectopic transglutaminase localization in OLP.", "subitem_description_type": "Abstract"}]}, "item_10001_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Sage Publications"}]}, "item_10001_relation_13": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "30213231", "subitem_relation_type_select": "PMID"}}]}, "item_10001_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "info:doi/10.1177/0300060518798261"}], "subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1177%2F0300060518798261", "subitem_relation_type_select": "DOI"}}]}, "item_10001_relation_17": {"attribute_name": "関連サイト", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "BioMed Central"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1177%2F0300060518798261", "subitem_relation_type_select": "DOI"}}, {"subitem_relation_name": [{"subitem_relation_name_text": "PubMed Central"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259409/", "subitem_relation_type_select": "URI"}}]}, "item_10001_rights_15": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "The Author(s) 2018"}]}, "item_10001_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1473-2300", "subitem_source_identifier_type": "ISSN"}]}, "item_10001_version_type_20": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Shimada, Katsumitsu"}], "nameIdentifiers": [{"nameIdentifier": "4911", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ochiai, Takanaga"}], "nameIdentifiers": [{"nameIdentifier": "4912", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hasegawa, Hiromasa"}], "nameIdentifiers": [{"nameIdentifier": "4913", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-11-07"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "2019-JA-007.pdf", "filesize": [{"value": "833.6 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_6", "mimetype": "application/pdf", "size": 833600.0, "url": {"label": "本文", "url": "https://mdu.repo.nii.ac.jp/record/2861/files/2019-JA-007.pdf"}, "version_id": "691cfac1-617f-49af-968c-f5fb505c4e3c"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Transglutaminase", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ectopic localization", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "hyperkeratosis", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "oral lichen planus", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "loricrin", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "involucrin", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "mucositis", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Ectopic transglutaminase 1 and 3 expression accelerating keratinization in oral lichen planus", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Ectopic transglutaminase 1 and 3 expression accelerating keratinization in oral lichen planus", "subitem_title_language": "en"}]}, "item_type_id": "10001", "owner": "3", "path": ["209", "499"], "permalink_uri": "https://mdu.repo.nii.ac.jp/records/2861", "pubdate": {"attribute_name": "公開日", "attribute_value": "2019-11-07"}, "publish_date": "2019-11-07", "publish_status": "0", "recid": "2861", "relation": {}, "relation_version_is_last": true, "title": ["Ectopic transglutaminase 1 and 3 expression accelerating keratinization in oral lichen planus"], "weko_shared_id": 3}