| Item type |
松本歯学/学術雑誌論文 / Journal Article(1) |
| 公開日 |
2019-11-07 |
| タイトル |
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|
タイトル |
Ectopic transglutaminase 1 and 3 expression accelerating keratinization in oral lichen planus |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Transglutaminase |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
ectopic localization |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
hyperkeratosis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
oral lichen planus |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
loricrin |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
involucrin |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
mucositis |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Shimada, Katsumitsu
Ochiai, Takanaga
Hasegawa, Hiromasa
|
| 著者別名 |
島田, 勝光
落合, 隆永
長谷川, 博雅
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Abstract Objective: Oral lichen planus (OLP) characterized by interface mucositis frequently shows hyper-keratinization. To clarify mechanisms of excess keratinization, we investigated key molecules for cornified cell envelope (CE). Methods: Involucrin (IVL), loricrin (LOR), transglutaminase 1 (TGase 1) and transglutaminase 3 (TGase 3) were immunohistochemically examined in 20 specimens of OLP; five specimens of buccal mucosa served as controls. Subsequently, the data were statistically analyzed. Results: IVL in OLP was localized in the cell membrane, in contrast to its localization in the cytoplasm in controls. No positive reaction indicative of LOR was noted in any specimens. Although the TGase 1 localization in controls was restricted to the upper three-quarters of the membrane, the localization in OLP was in both membrane and in the cytoplasm of full thickness mucosal layers. The TGase 3 localization pattern was dramatically altered from cytoplasmic to membranous in OLP. Conclusion: Our data suggest that aberrant TGase 1 and TGase 3 localization and distribution are closely related to hyper-keratinization in OLP. This is the first report of ectopic transglutaminase localization in OLP. |
| 書誌情報 |
en : The Journal of international medical research
巻 46,
号 11,
p. 4722-4730-4730,
発行日 2018-09-13
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| 出版者 |
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|
出版者 |
Sage Publications |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1473-2300 |
| PubMed番号 |
|
|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
PMID |
|
|
関連識別子 |
30213231 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.1177%2F0300060518798261 |
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|
関連名称 |
info:doi/10.1177/0300060518798261 |
| 権利 |
|
|
権利情報 |
The Author(s) 2018 |
| 関連サイト |
|
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1177%2F0300060518798261 |
|
|
関連名称 |
BioMed Central |
| 関連サイト |
|
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|
識別子タイプ |
URI |
|
|
関連識別子 |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259409/ |
|
|
関連名称 |
PubMed Central |
| フォーマット |
|
|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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