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Hypoxic Microenvironment and Metastatic Bone Disease
https://mdu.repo.nii.ac.jp/records/2873
https://mdu.repo.nii.ac.jp/records/2873317b7594-db87-4175-a001-9b3518fd6c44
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
本文 (416.8 kB)
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| Item type | 松本歯学/学術雑誌論文 / Journal Article(1) | |||||||
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| 公開日 | 2019-12-18 | |||||||
| タイトル | ||||||||
| タイトル | Hypoxic Microenvironment and Metastatic Bone Disease | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | hypoxia | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | hypoxia-inducible factors | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | bone metastasis | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| 著者 |
Hiraga, Toru
× Hiraga, Toru
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| 著者別名 |
平賀, 徹
× 平賀, 徹
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| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Hypoxia is a common feature of solid tumors and is associated with an increased risk of metastasis and a poor prognosis. Recent imaging techniques revealed that bone marrow contains a quite hypoxic microenvironment. Low oxygen levels activate hypoxia signaling pathways such as hypoxia-inducible factors, which play critical roles in the key stages of metastatic dissemination including angiogenesis, epithelial-mesenchymal transition, invasion, maintenance of cancer stemcells, tumor cell dormancy, release of extracellular vesicles, and generation of pre-metastatic niches. Hypoxia also affects bone cells, such as osteoblasts and osteoclasts, and immune cells, which also act to support the development and progression of bone metastases. Paradoxically, hypoxia and related signaling molecules are recognized as high-priority therapeutic targets and many candidate drugs are currently under preclinical and clinical investigation. The present review focuses on our current knowledge of the potential roles of hypoxia in cancer metastasis to bone by considering the interaction between metastatic cancer cells and the bone microenvironment. Current therapeutic approaches targeting hypoxia are also described. | |||||||
| 書誌情報 |
en : International journal of molecular sciences. 巻 19, 号 11, p. E3523, 発行日 2018-11-09 |
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| 出版者 | ||||||||
| 出版者 | MDPI | |||||||
| ISSN | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 1422-0067 | |||||||
| PubMed番号 | ||||||||
| 関連タイプ | isIdenticalTo | |||||||
| 識別子タイプ | PMID | |||||||
| 関連識別子 | 30423905 | |||||||
| DOI | ||||||||
| 関連タイプ | isIdenticalTo | |||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | https://doi.org/10.3390/ijms19113523 | |||||||
| 関連名称 | info:doi/10.3390/ijms19113523. | |||||||
| 権利 | ||||||||
| 権利情報 | © 2018 by the author. | |||||||
| 関連サイト | ||||||||
| 識別子タイプ | URI | |||||||
| 関連識別子 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274963/ | |||||||
| 関連名称 | PubMed Central | |||||||
| フォーマット | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | application/pdf | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
