| Item type |
松本歯学/学術雑誌論文 / Journal Article(1) |
| 公開日 |
2019-12-18 |
| タイトル |
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|
タイトル |
The Role of Transient Receptor Potential (TRP) Channels in the Transduction of Dental Pain |
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言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
dental pain |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
dentine hypersensitivity |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
pulpitis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
TRP channels |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
dental primary afferent neurons |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
odontoblasts |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
transduction mechanism |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Hossain, MZ
Bakri, MM
Yahya, Farhana
Ando, Hiroshi
Unno, Shumpei
Kitagawa, Junichi
|
| 著者別名 |
Hossain, MZ
Bakri, MM
Yahya, Farhana
安藤, 宏
海野, 俊平
北川, 純一
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| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
Dental pain is a common health problem that negatively impacts the activities of daily living. Dentine hypersensitivity and pulpitis-associated pain are among the most common types of dental pain. Patients with these conditions feel pain upon exposure of the affected tooth to various external stimuli. However, the molecular mechanisms underlying dental pain, especially the transduction of external stimuli to electrical signals in the nerve, remain unclear. Numerous ion channels and receptors localized in the dental primary afferent neurons (DPAs) and odontoblasts have been implicated in the transduction of dental pain, and functional expression of various polymodal transient receptor potential (TRP) channels has been detected in DPAs and odontoblasts. External stimuli-induced dentinal tubular fluid movement can activate TRP channels on DPAs and odontoblasts. The odontoblasts can in turn activate the DPAs by paracrine signaling through ATP and glutamate release. In pulpitis, inflammatory mediators may sensitize the DPAs. They could also induce post-translational modifications of TRP channels, increase trafficking of these channels to nerve terminals, and increase the sensitivity of these channels to stimuli. Additionally, in caries-induced pulpitis, bacterial products can directly activate TRP channels on DPAs. In this review, we provide an overview of the TRP channels expressed in the various tooth structures, and we discuss their involvement in the development of dental pain. |
| 書誌情報 |
en : International journal of molecular sciences.
巻 20,
号 3,
発行日 2019-01-27
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| 出版者 |
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出版者 |
MDPI |
| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1422-0067 |
| PubMed番号 |
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関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
PMID |
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関連識別子 |
30691193 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.3390/ijms20030526 |
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関連名称 |
info:doi/ 10.3390/ijms20030526 |
| 権利 |
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|
権利情報 |
© 2019 by the authors. |
| 関連サイト |
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識別子タイプ |
URI |
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関連識別子 |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387147/ |
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|
関連名称 |
PubMed Central |
| フォーマット |
|
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内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| 著者版フラグ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
本文 (1.7 MB)
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