{"_buckets": {"deposit": "721bab3f-fa8d-47be-9e0e-f48aa3f739ae"}, "_deposit": {"created_by": 3, "id": "2875", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "2875"}, "status": "published"}, "_oai": {"id": "oai:mdu.repo.nii.ac.jp:00002875", "sets": ["411", "412", "421", "422", "438"]}, "author_link": ["5021", "5022", "5015", "5018", "5019", "5017", "5020", "5023", "5013", "5014", "5024", "5016"], "item_10001_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2019-01-27", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3", "bibliographicVolumeNumber": "20", "bibliographic_titles": [{}, {"bibliographic_title": "International journal of molecular sciences.", "bibliographic_titleLang": "en"}]}]}, "item_10001_creator_3": {"attribute_name": "著者別名", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Hossain, MZ"}], "nameIdentifiers": [{"nameIdentifier": "5019", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Bakri, MM"}], "nameIdentifiers": [{"nameIdentifier": "5020", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yahya, Farhana"}], "nameIdentifiers": [{"nameIdentifier": "5021", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "安藤, 宏"}], "nameIdentifiers": [{"nameIdentifier": "5022", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "海野, 俊平"}], "nameIdentifiers": [{"nameIdentifier": "5023", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "北川, 純一"}], "nameIdentifiers": [{"nameIdentifier": "5024", "nameIdentifierScheme": "WEKO"}]}]}, "item_10001_description_19": {"attribute_name": "フォーマット", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_10001_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Dental pain is a common health problem that negatively impacts the activities of daily living. Dentine hypersensitivity and pulpitis-associated pain are among the most common types of dental pain. Patients with these conditions feel pain upon exposure of the affected tooth to various external stimuli. However, the molecular mechanisms underlying dental pain, especially the transduction of external stimuli to electrical signals in the nerve, remain unclear. Numerous ion channels and receptors localized in the dental primary afferent neurons (DPAs) and odontoblasts have been implicated in the transduction of dental pain, and functional expression of various polymodal transient receptor potential (TRP) channels has been detected in DPAs and odontoblasts. External stimuli-induced dentinal tubular fluid movement can activate TRP channels on DPAs and odontoblasts. The odontoblasts can in turn activate the DPAs by paracrine signaling through ATP and glutamate release. In pulpitis, inflammatory mediators may sensitize the DPAs. They could also induce post-translational modifications of TRP channels, increase trafficking of these channels to nerve terminals, and increase the sensitivity of these channels to stimuli. Additionally, in caries-induced pulpitis, bacterial products can directly activate TRP channels on DPAs. In this review, we provide an overview of the TRP channels expressed in the various tooth structures, and we discuss their involvement in the development of dental pain.", "subitem_description_type": "Abstract"}]}, "item_10001_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "MDPI"}]}, "item_10001_relation_13": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "30691193", "subitem_relation_type_select": "PMID"}}]}, "item_10001_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "info:doi/ 10.3390/ijms20030526"}], "subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.3390/ijms20030526", "subitem_relation_type_select": "DOI"}}]}, "item_10001_relation_17": {"attribute_name": "関連サイト", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "PubMed Central"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387147/", "subitem_relation_type_select": "URI"}}]}, "item_10001_rights_15": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2019 by the authors."}]}, "item_10001_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1422-0067", "subitem_source_identifier_type": "ISSN"}]}, "item_10001_version_type_20": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Hossain, MZ"}], "nameIdentifiers": [{"nameIdentifier": "5013", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Bakri, MM"}], 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"future_date_message": "", "is_thumbnail": false, "licensetype": "license_6", "mimetype": "application/pdf", "size": 1700000.0, "url": {"label": "本文", "url": "https://mdu.repo.nii.ac.jp/record/2875/files/2019-JA-010.pdf"}, "version_id": "5c9e35d5-bb88-4f5b-b04b-a6046ec49cfb"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "dental pain", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "dentine hypersensitivity", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "pulpitis", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "TRP channels", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "dental primary afferent neurons", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "odontoblasts", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "transduction mechanism", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "The Role of Transient Receptor Potential (TRP) Channels in the Transduction of Dental Pain", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "The Role of Transient Receptor Potential (TRP) Channels in the Transduction of Dental Pain", "subitem_title_language": "en"}]}, "item_type_id": "10001", "owner": "3", "path": ["411", "412", "421", "422", "438"], "permalink_uri": "https://mdu.repo.nii.ac.jp/records/2875", "pubdate": {"attribute_name": "公開日", "attribute_value": "2019-12-18"}, "publish_date": "2019-12-18", "publish_status": "0", "recid": "2875", "relation": {}, "relation_version_is_last": true, "title": ["The Role of Transient Receptor Potential (TRP) Channels in the Transduction of Dental Pain"], "weko_shared_id": 3}