{"_buckets": {"deposit": "7b7cceb1-f3dd-4b95-94a0-cca4ee58f95a"}, "_deposit": {"created_by": 3, "id": "2880", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "2880"}, "status": "published"}, "_oai": {"id": "oai:mdu.repo.nii.ac.jp:00002880", "sets": ["195", "357", "510"]}, "author_link": ["5065", "5064", "5069", "5070", "5072", "5066", "5071", "5067", "5068", "5063"], "item_10001_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2018-11-13", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageStart": "122", "bibliographicVolumeNumber": "5", "bibliographic_titles": [{}, {"bibliographic_title": "Medicines", "bibliographic_titleLang": "en"}]}]}, "item_10001_creator_3": {"attribute_name": "著者別名", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "荒, 敏昭"}], "nameIdentifiers": [{"nameIdentifier": "5068", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "中谷, 幸枝"}], "nameIdentifiers": [{"nameIdentifier": "5069", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "古旗, 賢二"}], "nameIdentifiers": [{"nameIdentifier": "5070", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "十川, 紀夫"}], "nameIdentifiers": [{"nameIdentifier": "5071", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "十川, 千春"}], "nameIdentifiers": [{"nameIdentifier": "5072", "nameIdentifierScheme": "WEKO"}]}]}, "item_10001_description_19": {"attribute_name": "フォーマット", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_10001_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "The oral inflammatory diseases are divided into two types: acute and chronic inflammatory diseases. In this review, we summarize the biological efficacy of herbal medicine, natural products, and their active ingredients against acute and chronic inflammatory diseases in the oral region, especially stomatitis and periodontitis. We review the effects of herbal medicines and a biscoclaurin alkaloid preparation, cepharamthin, as a therapy against stomatitis, an acute inflammatory disease. We also summarize the effects of herbal medicines and natural products against periodontitis, a chronic inflammatory disease, and one of its clinical conditions, alveolar bone resorption. Recent studies show that several herbal medicines such as kakkonto and ninjinto reduce LPS-induced PGE 2 production by human gingival fibroblasts. Among herbs constituting these herbal medicines, shokyo (Zingiberis Rhizoma) and kankyo (Zingiberis Processum Rhizoma) strongly reduce PGE 2 production. Moreover, anti-osteoclast activity has been observed in some natural products with anti-inflammatory effects used against rheumatoid arthritis such as carotenoids, flavonoids, limonoids, and polyphenols. These herbal medicines and natural products could be useful for treating oral inflammatory diseases. ", "subitem_description_type": "Abstract"}]}, "item_10001_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "MDPI"}]}, "item_10001_relation_13": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "30428613", "subitem_relation_type_select": "PMID"}}]}, "item_10001_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "info:doi/10.3390/medicines5040122"}], "subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://www.mdpi.com/2305-6320/5/4/122/htm", "subitem_relation_type_select": "DOI"}}]}, "item_10001_relation_17": {"attribute_name": "関連サイト", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "PubMed Central"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313758/", "subitem_relation_type_select": "URI"}}]}, "item_10001_rights_15": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2018 by the authors"}]}, "item_10001_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1422-0067", "subitem_source_identifier_type": "ISSN"}]}, "item_10001_version_type_20": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Ara, Toshiaki"}], "nameIdentifiers": [{"nameIdentifier": "5063", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakatani, Schie"}], "nameIdentifiers": [{"nameIdentifier": "5064", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kobata, Kenji"}], "nameIdentifiers": [{"nameIdentifier": "5065", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sogawa, Norio"}], "nameIdentifiers": [{"nameIdentifier": "5066", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sogawa, Chiharu"}], "nameIdentifiers": [{"nameIdentifier": "5067", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-12-18"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "2019-JA-011.pdf", "filesize": [{"value": "657.8 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_6", "mimetype": "application/pdf", "size": 657800.0, "url": {"label": "本文", "url": "https://mdu.repo.nii.ac.jp/record/2880/files/2019-JA-011.pdf"}, "version_id": "c8c1b668-1f66-4219-89a4-1488bf116540"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "inflammatory disease", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "stomatitis", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "periodontitis", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "anti-osteoclast activity", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "cepharanthin", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "herbal medicine", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "natural product", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "arachidonic acid cascade", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "The Biological Efficacy of Natural Products against Acute and Chronic Inflammatory Diseases in the Oral Region", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "The Biological Efficacy of Natural Products against Acute and Chronic Inflammatory Diseases in the Oral Region", "subitem_title_language": "en"}]}, "item_type_id": "10001", "owner": "3", "path": ["195", "357", "510"], "permalink_uri": "https://mdu.repo.nii.ac.jp/records/2880", "pubdate": {"attribute_name": "公開日", "attribute_value": "2019-12-18"}, "publish_date": "2019-12-18", "publish_status": "0", "recid": "2880", "relation": {}, "relation_version_is_last": true, "title": ["The Biological Efficacy of Natural Products against Acute and Chronic Inflammatory Diseases in the Oral Region"], "weko_shared_id": 3}