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天然甘味料,Steviosideの一般薬理試験
https://mdu.repo.nii.ac.jp/records/321
https://mdu.repo.nii.ac.jp/records/321d5a39650-2026-42cd-9224-3df3eb70e2de
| 名前 / ファイル | ライセンス | アクション |
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matsumoto_shigaku_08-01-06.pdf (416.1 kB)
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| Item type | Journal Article(1) | |||||||
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| 公開日 | 2012-05-23 | |||||||
| タイトル | ||||||||
| タイトル | 天然甘味料,Steviosideの一般薬理試験 | |||||||
| 言語 | ||||||||
| 言語 | jpn | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| その他（別言語等）のタイトル | ||||||||
| その他のタイトル | Pharmacological Studies of Stevioside | |||||||
| 著者 |
倉橋, 寿
× 倉橋, 寿
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| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Stevioside is a kind of diterpen glycoside which is two or three hundred times as sweet as suger, and is contained about 7% in the dried leaves of Stevia rebaudiana Bertoni in Chrysanthemum family. It has been used as wild sweetening in Paraguay for a long time. Many researchers have been engaged in studying about the method of cultivation and extraction of sweetening since it was introduced to Japan in 1971. In the field of dentistry, it is noticed as substitute sweetening for suger which causes the increase of dental caries. It is necessary to ascertain whether the new sweetening is safe or not. However, few data have been issued until a recent date. So the pharmacology of stevioside was investigated. Two kinds of purity, 93% (S-93) and 69% (S-69), of stevioside extracted from dried Stevia leaves were used. The sweetness test by human tongues showed that S-69 was one hundred and twenty times as sweet as sucrose. In the liking test by male rats, S-69 solutions which contain from 0.01% to 0.08% were drunk about 1.4 to 2.1 times as compared with water. On the LD 50 of S-69 on male mice, they were 0.89g/kg by intravenous injection (I. V.), 1.38g/kg by intraperitoneal injection (I. P.) and 1.67g/kg by subcutaneous injection (S. C) respectively. But no mice died by even 16g/kg of oral administration (P. O.). The respiration, blood pressure, cardiogram and body temperature of male rabbits did not change when 15g/kg of S-69 was administrated orally. But, blood pressure and heart beats were decreased, and respiration number and capacity were increased when 0.4g/kg of S-69 was administrated by I. V.. In connection with S-69 and central nervous system stimulants and depressants, there was no statistical significance of motality when 5.8mg/kg of picrotoxin or 1mg/kg of strychinine nitrate was injected into male mice intraperitoneally after the oral administration of 2g/kg of S-69. The staitstical significance of sleeping time was not observed when 70mg/kg of hexobarbital was injected into male mice intraperitoneally after oral administration of 0.5g/kg of S-93. As for the effect on pain, there was no statistical significance of writhing syndrome when 0.1ml per 10g body weight of 0.6% acetic acid was injected into male mice intraperitoneally after the oral administration of 2g/kg of S-69. As for the effect on membranes, any change was not to be seen when 0.2ml of 5% S-69 was dropped in an eye of male rabbits, and 20% S-69 was applied to the skin of male mice. As for the effect on removed internal organs, the amplitude of bullfrogs' heart was somewhat suppressed above the concentration of 0.2mg/ml of S-93. The amplitude of rabbits' intestine was suppressed more than 50% above 3.2mg/ml of S-69 and S-93. The shrink of guinea pigs' ileum on histamine hydrochloride (final concentration: 0.2mcg/ml) was not affected by S-93, but it occured more than 50% above the concentration of 4mg/ml of S-69. | |||||||
| 書誌情報 |
松本歯学 巻 8, 号 1, p. 56-62, 発行日 1982-06-30 |
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| 出版者 | ||||||||
| 出版者 | 松本歯科大学学会 | |||||||
| ISSN | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 0385-1613 | |||||||
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| 収録物識別子タイプ | NCID | |||||||
| 収録物識別子 | AN00232590 | |||||||
| フォーマット | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | application/pdf | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
