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表層拡大型腫瘍の臨床病理学的および分子生物学的特徴 : 大腸腫瘍の側方増殖型腫瘍
https://mdu.repo.nii.ac.jp/records/594
https://mdu.repo.nii.ac.jp/records/594a07c3084-d9b0-465b-902a-421b0de0b46d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
matsumoto_shigaku_29-01-01.pdf (2.2 MB)
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| Item type | Journal Article(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| 公開日 | 2012-05-24 | |||||||
| タイトル | ||||||||
| タイトル | 表層拡大型腫瘍の臨床病理学的および分子生物学的特徴 : 大腸腫瘍の側方増殖型腫瘍 | |||||||
| 言語 | ||||||||
| 言語 | jpn | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | laterally spreading tumour | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | colorectum | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | apoptosis | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | morphogenesis | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| その他（別言語等）のタイトル | ||||||||
| その他のタイトル | Clinicopathological and molecular biological characteristics of superficial spreading type tumor "Laterally spreading tumor of colorectum" | |||||||
| 著者 |
長谷川, 博雅
× 長谷川, 博雅
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| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Laterally spreading tumor (LST) of colon and rectum shows unique characteristics of horizontal-dominant intramucosal growth over 10mm in diameter, although polypoidtype tumor reveals vertical dominant growth. It was divided into two subtypes such as granular and non-granular or flat types. The former shows small-granular surface consisting of granules, measuring 1.2±0.3mm, that are mostly less than 3mm in diameter. So we prefer the name of granule aggregating tumor (GAT) to nodule aggregating tumor. While the latter has a strikingly unique margin, which protrudes outside like amoebase's pseudopodia, called as "pseudopodial-like appearance". Interestingly, histological investigations seldom reveal carcinomatous components involving the submucosa of GATs even if it is more than 20mm in size, in contrast to relatively frequent submucosal invasion in the nongranular or flat type. Microsatellite instability (MSI) was detected in only one case of our LST series. More than 80% of LSTs over-expressed β-catenin protein, accompanied by p 53 expression that correlated with atypia. Considering mutations of many oncogenes and tumor suppressor genes investigated in polypoid-type tumors, results of β-catenin and p 53 expressions seem to be consistent with "adenoma-carcinoma sequence theory". The apoptosis index of the lower part of granule-aggregating tumors was significantly higher than that of the lower part (4.44±1.81 vs. 1.21±1.47 in TUNEL). Acceleration of apoptosis in cells of lower part of granule aggregating tumors may inhibit the vertical growth and result in its characteristic morphogenesis. | |||||||
| 書誌情報 |
松本歯学 巻 29, 号 1, p. 1-10, 発行日 2003-04-30 |
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| 出版者 | ||||||||
| 出版者 | 松本歯科大学学会 | |||||||
| ISSN | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 0385-1613 | |||||||
| 書誌レコードID | ||||||||
| 収録物識別子タイプ | NCID | |||||||
| 収録物識別子 | AN00232590 | |||||||
| フォーマット | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | application/pdf | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
