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有害金属の生体影響(ヒ素に関連して)および有害金属拮抗薬DMSA, DMPSについて
https://mdu.repo.nii.ac.jp/records/757
https://mdu.repo.nii.ac.jp/records/757bbfcaad2-76c3-4af1-a545-18a45cd0e6a8
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
matsumoto_shigaku_23-03-01.pdf (481.1 kB)
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| Item type | Journal Article(1) | |||||||
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| 公開日 | 2012-05-24 | |||||||
| タイトル | ||||||||
| タイトル | 有害金属の生体影響(ヒ素に関連して)および有害金属拮抗薬DMSA, DMPSについて | |||||||
| 言語 | ||||||||
| 言語 | jpn | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | biotransformation of arsenic | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | DMSA | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | DMPS | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| その他（別言語等）のタイトル | ||||||||
| その他のタイトル | On the Toxicology of Metals with a Special Emphasis on the Biotransformation of Arsenic and Metal Chelating Agents, DMSA and DMPS | |||||||
| 著者 |
前橋, 浩
× 前橋, 浩
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| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Great concerns of investigators engaging in studies of toxicology of arsenic have been focused on the biotransformation of inorganic arsenic. The first in the world, Aposhian's group purified partially the enzyme(s), arsenite methyltransferase and also monomethylarsonate methyltransferase in rabbit livers. Methyltransferase is considered a key enzyme related to arsenic detoxification, because methylated arsenic species (organic arsenic) are much less toxic than inorganic arsenic. In a recent discovery, some animals such as marmosets, guinea pigs and chimpanzees were found not to have the enzyme and therefore are unable to detoxify the toxic inorganic arsenic compounds. Aposhian speculated the reason for deficiency of this enzyme in these animals from a view point of revolutionary natural selection. Among similar heavy metal antagonists, DMSA has been already approved as a drug of choice in the US for children suffering from heavy lead poisoning. On the other hand, DMPS has not yet been approved. Aposhian's group adopted DMPS as a chemical of a challenge test for the evaluation of toxic metal loads on the human body. They evaluated mercury loads on the subjects with amalgam in their teeth and another groups of subjects consisting of dentists and dental technicians dealing with mercury at one particular dental clinic. These subjects responded well to the challenge test, showing a substantial amount of mercury excreted in urine as compared with the respective control. However, in the case of arsenic after the challenge dose of DMPS, subjects highly exposed to arsenic in drinking water excreted high concentrations of total arsenic in urine, but a different rate was observed among amounts of detected metabolites of arsenic from that of control group. | |||||||
| 書誌情報 |
松本歯学 巻 23, 号 3, p. 145-153, 発行日 1997-12-31 |
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| 出版者 | ||||||||
| 出版者 | 松本歯科大学学会 | |||||||
| ISSN | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 0385-1613 | |||||||
| 書誌レコードID | ||||||||
| 収録物識別子タイプ | NCID | |||||||
| 収録物識別子 | AN00232590 | |||||||
| フォーマット | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | application/pdf | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
