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有害金属拮抗薬DMSAおよびDMPSについて
https://mdu.repo.nii.ac.jp/records/1101
https://mdu.repo.nii.ac.jp/records/11013b1b3f82-f7b3-4f4a-944b-68de8004882f
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
matsumoto_shigaku_16-02-01.pdf (455.7 kB)
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| Item type | Journal Article(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| 公開日 | 2012-05-24 | |||||||
| タイトル | ||||||||
| タイトル | 有害金属拮抗薬DMSAおよびDMPSについて | |||||||
| 言語 | ||||||||
| 言語 | jpn | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | DMSA | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | DMPS | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | 重金属拮抗薬 | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| その他（別言語等）のタイトル | ||||||||
| その他のタイトル | Metal Chelating Agents with Special Reference to DMSA and DMPS | |||||||
| 著者 |
前橋, 浩
× 前橋, 浩
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| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | 2, 3-dimercaptosuccinic acid (DMSA) and 2, 3-dimercapto-1-propanesulfonic acid Na salt (DMPS), have been studied extensively by Aposhian's group as promising substitutes for 2, 3-dimercaptopropanol (BAL), a widely used antidote for arsenic (but which has been subject to controversy due to undesirable side effects when used clinically), as well as for possible use against mercury, lead, and other heavy metal intoxication. In contrast with BAL, both DMSA and DMPS show lower toxicity and are effective when administered orally. Many clinical trials have proved DMSA safe and well tolerated by patients. On the whole, the efficacy as antidotes is the same for both DMSA and DMPS. However, the LD_50 of DMSA in mammals is almost 3 times greater than that of DMPS. In arsenic poisoned rats, DMSA promoted excretion of arsenic via urine, while DMPS eliminated the poison through the bile. This difference in the route of elimination accords with pharmacokinetic studies showing that DMSA is distributed mainly extracellularly, and DMPS mainly intracellularly. These contrasting distributions explain the lower toxicity of DMSA compared with DMPS. Accordingly, of these two metal chelating agents, DMSA appears the more likely candidate to receive recommendation as a clinically useful drug in the future. | |||||||
| 書誌情報 |
松本歯学 巻 16, 号 2, p. 125-132, 発行日 1990-08-31 |
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| 出版者 | ||||||||
| 出版者 | 松本歯科大学学会 | |||||||
| ISSN | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 0385-1613 | |||||||
| 書誌レコードID | ||||||||
| 収録物識別子タイプ | NCID | |||||||
| 収録物識別子 | AN00232590 | |||||||
| フォーマット | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | application/pdf | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
