WEKO3
アイテム
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Preventive effects of a Kampo Medicine, Shosaikoto, on inflammatory responses in LPS-Treated Human gingival fibroblasts
https://mdu.repo.nii.ac.jp/records/2279
https://mdu.repo.nii.ac.jp/records/2279f382463e-f54d-48ee-8bfd-61cd9bc665ee
名前 / ファイル | ライセンス | アクション |
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2014-004_JA.pdf (156.2 kB)
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Item type | 松本歯学/学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2014-10-06 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Preventive effects of a Kampo Medicine, Shosaikoto, on inflammatory responses in LPS-Treated Human gingival fibroblasts | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Shosaikoto | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | periodontal disease | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | gingival fibroblast | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | lipopolysaccharide | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Anti-Inflammatory Agents, Non-Steroidal | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Drugs, Chinese Herbal | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Fibroblasts | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Gingiva | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Lipopolysaccharides | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Medicine, Kampo | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
その他(別言語等)のタイトル | ||||||
その他のタイトル | LPS処理したヒト歯肉線維芽細胞の炎症反応に及ぼす漢方薬小柴胡湯の予防効果 | |||||
著者 |
ARA, TOSHIAKI
× ARA, TOSHIAKI× MAEDA, YOSHIHIRO× FUJINAMI, YOSHIAKI× IMAMURA, YASUHIRO× HATTORI, TOSHIMI× WANG, PAO-LI |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In the present study, we investigated the anti-inflammatory effects of a Kampo medicine Shosaikoto (TJ-9) using in vitro periodontal disease model, in which human gingival fibroblasts (HGFs) treated with lipopolysaccharide (LPS) from Porphyromonas gingivalis (PgLPS) produce IL-6, IL-8 and prostaglandin E2 (PGE2). Treatment with PgLPS (10 ng/ml), TJ-9 (up to 1 mg/ml) and their combinations for 24 h did not affect the viability of HGFs. Moreover, TJ-9 did not alter LPS-induced IL-6 and IL-8 productions. However, TJ-9 significantly suppressed LPS-induced PGE2 production in a dose-dependent manner but TJ-9 alone did not affect basal PGE2 level. Western blotting demonstrated that TJ-9 decreased cyclooxygenase-2 (COX-2) expression in a dosedependent manner but not phospholipase A2. Moreover, TJ-9 selectively and dose-dependently inhibited COX-2 activity. These results suggest that TJ-9 decreased PGE2 production by inhibition of both COX-2 expression and activity and that TJ-9 may be useful to improve gingival inflammation in periodontal disease. | |||||
書誌情報 |
en : Biological and Pharmaceutical Bulletin 巻 31, 号 6, p. 1141-1144, 発行日 2008-06-01 |
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出版者 | ||||||
出版者 | Pharmaceutical Society of Japan | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1347-5215 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10885497 | |||||
NII論文ID | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | NAID | |||||
関連識別子 | 110006684330 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/18520044 | |||||
医中誌ID | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | ICHUSHI | |||||
関連識別子 | 2008327109 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1248/bpb.31.1141 | |||||
関連名称 | info:doi/10.1248/bpb.31.1141 | |||||
権利 | ||||||
権利情報 | Copy right © THE PHARMACEUTICAL SOCIETY OF JAPAN 2008 | |||||
関連サイト | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1248/bpb.31.1141 | |||||
関連名称 | J-STAGE | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |