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骨格筋におけるNaFの収縮増強作用
https://mdu.repo.nii.ac.jp/records/264
https://mdu.repo.nii.ac.jp/records/264442ff045-6638-4b06-985a-ff7cd9363eaa
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
matsumoto_shigaku_06-02-02.pdf (452.6 kB)
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| Item type | Journal Article(1) | |||||||
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| 公開日 | 2012-05-23 | |||||||
| タイトル | ||||||||
| タイトル | 骨格筋におけるNaFの収縮増強作用 | |||||||
| 言語 | ||||||||
| 言語 | jpn | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| その他（別言語等）のタイトル | ||||||||
| その他のタイトル | Augmentation of Skeletal Muscle Contraction by NaF | |||||||
| 著者 |
服部, 敏己
× 服部, 敏己
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| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | For the purpose of elucidation of the mechanism of convulsion induced as the acute intoxication of sodium fluoride (NaF), the actions of NaF on the frog sciatic nerve-sar-torius muscle preparation were investigated electrophysiologically. The results obtained were summarised as follows: 1) Both twitch and tetanus tension were augmented by NaF dose-dependently. 2) NaF had little effect on the compound action potential of nerves, resting membrane potential, action potential and membrane resistance of muscle fibre. 3) NaF augmented the amplitude, rate of rise and half decay time of endplate potential dose-dependently. 4) NaF augmented both the frequency and the amplitude of miniature endplate potential (MEPP). 5) The amount of neostigmine which inhibits more than 80% of cholinesterases had no effect on the action of NaF on MEPP amplitude. These results suggest that NaF facilitates acetylcholine release from the presynaptic membrane, sensitizes the cholinergic receptor of the postsynaptic membrane and inhibits the cholinesterase in the neuromuscular junction, and that these actions of NaF are involved in augmentation of muscle contraction and the convulsion. | |||||||
| 書誌情報 |
松本歯学 巻 6, 号 2, p. 153-160, 発行日 1980-12-31 |
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| 出版者 | ||||||||
| 出版者 | 松本歯科大学学会 | |||||||
| ISSN | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 0385-1613 | |||||||
| 書誌レコードID | ||||||||
| 収録物識別子タイプ | NCID | |||||||
| 収録物識別子 | AN00232590 | |||||||
| フォーマット | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | application/pdf | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
