| Item type |
松本歯学/学術雑誌論文 / Journal Article(1) |
| 公開日 |
2018-03-07 |
| タイトル |
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タイトル |
Overview of Cytological Dynamics of Periodontal Ligament Inflammatory Lesions |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
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|
言語 |
en |
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主題Scheme |
Other |
|
主題 |
Chronic Apical Periodontitis |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
Alveolar Abscess |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
Chronic Proliferelative Periodontal Inflammatory Lesion |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
Periodontal Polyp |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
Granulation Tissue |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Periodontal Ligament |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Cell Differentiation |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Cell Migration |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Undifferentiated Mesenchymal Cells |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Bone Marrow |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
MATSUDA, SAEKA
NAKANO, K
TSUJIGIWA, H
TAKABATAKE, K
OKAFUJI, N
SHOUMURA, M
OSUGA, N
NAGATSUKA, H
KAWAKAMI, T
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Cyto-pathological features of the periodontal ligament tissue inflammatory lesions have somehow been carried out but detailed cellular dynamics remain unclear. Therefore, in this review, we overviewed mainly our recent experimental model studies. That is performed using using ordinary ddY mice and BMP bone marrow transplanted mouse model. Regaring the experimental apical inflammatory periodontitis, at four weeks, micro-CT confirmed the presence of a radiolucent image at the apex of the tooth, which was then removed for histological examination. The results showed granulation tissue with fibrosis gradually formed at the periphery of an abscess. Next, if perforation were large, granulation tissue would grow to form periodontal polyp. Results of micro-CT revealed alveolar bone resorption and widening of periodontal ligament. Histopathological examination showed proliferation of fibroblasts with some round cells and blood vessels in the granulation tissue. Double immunofluorescent staining of GFP and Runx2 revealed that both proteins were expressed in spindle-shaped cells. Double immunofluorescent staining of GFP and CD31 revealed that both proteins were expressed in vascular endothelial cells in morphologically distinct vessels. The results suggest that fibroblasts, periodontal ligament fibroblasts and blood vessels in granulation tissue were derived from transplanted-bone marrow cells. Thus, essential growth of granulation tissue in periodontal polyp was caused by the migration of undifferentiated mesenchymal cells derived from bone marrow, which differentiated into fibroblasts and later on differentiated into other cells in response to injury. |
| 書誌情報 |
en : International Journal of Dentistry and Oral Science
巻 S9,
号 001,
p. 1-7,
発行日 2016-09-08
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| 出版者 |
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出版者 |
SciDoc Publishers |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
2377-8075 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
http://dx.doi.org/10.19070/2377-8075-SI09001 |
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関連名称 |
info:doi/10.19070/2377-8075-SI09001 |
| 権利 |
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権利情報 |
Copyright: Kawakami T© 2016. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distributionand reproduction in any medium, provided the original author and source are credited. |
| 情報源 |
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関連名称 |
雑誌掲載論文(電子版) |
| 関連サイト |
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識別子タイプ |
URI |
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関連識別子 |
https://scidoc.org/IJDOSS9.php |
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関連名称 |
SciDoc Publishers |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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