| Item type |
松本歯学/学術雑誌論文 / Journal Article(1) |
| 公開日 |
2019-05-15 |
| タイトル |
|
|
タイトル |
SQUAMOUS ODONTOGENIC TUMOR OF THE MANDIBLE: A CASE REPORT DEMONSTRATING IMMUNOEXPRESSION OF NOTCH1, 3, 4, JAGGED1 AND DELTA1 |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
solitary odontogenic tumor |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Notch signaling |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
immunohistochemistry |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
cytodifferentiation\n |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Siar, CH
Nakano, K
Ng, KH
Tomida, M
Nagatsuka H
Kawakami T
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background:Squamous odontogenic tumor (SOT) is a rare benign odontogenic epithelial neoplasm. A slow-growing painless expansive swelling is the common presenting symptom. Histopathologically, SOT can be easily misdiagnosed as an acanthomatous ameloblastoma. Although Notch receptors and ligands have been shown to play a role in cell fate decisions in ameloblastomas, the role of these cell signaling molecules in SOT is unknown. Case report:This paper describes a case of SOT affecting the anterior mandible of a 10-year-old Indian female. The patient was treated by local surgical excision and there has been no follow-up clinical record of recurrence 5 years after primary treatment. Histopathological examination revealed a solid, locally-infiltrative neoplasm composed of bland-looking squamatoid islands scattered in a mature fibrous connective tissue stroma and the diagnosis was SOT. Immunohistochemical evaluation showed positive reactivity of varying intensity in the neoplastic epithelial cells for Notch1, Notch3, Notch4, and their ligands Jagged1 and Delta1. Expression patterns showed considerable overlap. No immunoreactivity was detected for Notch2 and Jagged2. Conclusions:Present findings suggest that Notch receptors and their ligands play differential roles in the cytodifferentiation of SOT. |
| 書誌情報 |
en : European journal of medical research
巻 15,
号 4,
p. 180-184-184,
発行日 2010-04-08
|
| 出版者 |
|
|
出版者 |
I. Holzapfel(BioMed Central) |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
2047-783X |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11331989 |
| PubMed番号 |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
info:pmid/20554499 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1186/2047-783X-15-4-180 |
|
|
関連名称 |
info:doi/10.1186/2047-783X-15-4-180 |
| 権利 |
|
|
権利情報 |
© I. Holzapfel Publishers 2010. licensed under the Creative Commons Attribution License 4.0. (https://creativecommons.org/licenses/by/4.0/legalcode) |
| 関連サイト |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1186/2047-783X-15-4-180 |
|
|
関連名称 |
BioMed Central |
| 関連サイト |
|
|
|
識別子タイプ |
URI |
|
|
関連識別子 |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401003/ |
|
|
関連名称 |
PubMed Central |
| フォーマット |
|
|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
本文 (5.7 MB)
.png)
