| Item type |
松本歯学/学術雑誌論文 / Journal Article(1) |
| 公開日 |
2019-05-15 |
| タイトル |
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タイトル |
Notch signaling acts on cell differentiation and acquisition of tumor-specific character of oral neoplasms |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
odontogenic tumor |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
pleomorphic adenoma |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
notch signaling |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
cell differentiation |
| キーワード |
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言語 |
en |
|
主題Scheme |
Other |
|
主題 |
immunohistochemistry |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
epithelial-mesenchymal interaction |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
malignant transformation |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Keisuke, Nakano
Kiyofumi, Takabatake
Hotaka, Kawai
Saori, Yoshida
Hatsuhiko, Maeda
Toshiyuki, Kawakami
Hitoshi, Nagatsuka 1
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Histopathological findings of oral neoplasm cell differentiation and metaplasia suggest that tumor cells induce their own dedifferentiation and re-differentiation and may lead to the formation of tumor-specific histological features. Notch signaling is involved in the maintenance of tissue stem cell nature and regulation of differentiation and is responsible for the cytological regulation of cell fate, morphogenesis, and/or development. In our previous study, immunohistochemistry was used to examine Notch expression using cases of odontogenic tumors and pleomorphic adenoma as oral neoplasms. According to our results, Notch signaling was specifically associated with tumor cell differentiation and metaplastic cells of developmental tissues. Notch signaling was involved in the differentiation of the ductal epithelial cells of salivary gland tumors and ameloblast-like cells of odontogenic tumors. However, Notch signaling was also involved in squamous metaplasia, irrespective of the type of developmental tissue. In odontogenic tumors, Notch signaling was involved in epithelial–mesenchymal interactions and may be related to tumor development and tumorigenesis. This signaling may also be associated with the malignant transformation of ameloblastomas. Overall, Notch signaling appears to play a major role in the formation of the characteristic cellular composition and histological features of oral neoplasms, and this involvement has been reviewed here. |
| 書誌情報 |
en : International Journal of Molecular Sciences
巻 20,
号 8,
p. 1973,
発行日 2019
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| 出版者 |
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出版者 |
MDPI AG |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1422-0067 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.3390/ijms20081973 |
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関連名称 |
info:doi/10.3390/ijms20081973 |
| 権利 |
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|
権利情報 |
© by the authors. Licensee MDPI, Basel, Switzerland. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0). (http://creativecommons.org/licenses/by/4.0]/) |
| 関連サイト |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.3390/ijms20081973 |
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関連名称 |
MDPI |
| フォーマット |
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内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
本文 (6.7 MB)
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