| Item type |
松本歯学/学術雑誌論文 / Journal Article(1) |
| 公開日 |
2019-12-18 |
| タイトル |
|
|
タイトル |
Activation of TRPV1 and TRPM8 Channels in the Larynx and Associated Laryngopharyngeal Regions Facilitates the Swallowing Reflex |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
TRPV1 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
TRPM8 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Superior laryngeal nerve |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Swallowing reflex |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Dysphagia |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Hossain, MZ
Ando, Hiroshi
Unno, Shumpei
Masuda, Yuji
Kitagawa, Junichi
|
| 著者別名 |
Hossain, MZ
安藤, 宏
海野, 俊平
増田, 裕次
北川, 純一
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The larynx and associated laryngopharyngeal regions are innervated by the superior laryngeal nerve (SLN) and are highly reflexogenic. Transient receptor potential (TRP) channels have recently been detected in SLN innervated regions; however, their involvement in the swallowing reflex has not been fully elucidated. Here, we explore the contribution of two TRP channels, TRPV1 and TRPM8, located in SLN-innervated regions to the swallowing reflex. Immunohistochemistry identified TRPV1 and TRPM8 on cell bodies of SLN afferents located in the nodose-petrosal-jugular ganglionic complex. The majority of TRPV1 and TRPM8 immunoreactivity was located on unmyelinated neurons. Topical application of different concentrations of TRPV1 and TRPM8 agonists modulated SLN activity. Application of the agonists evoked a significantly greater number of swallowing reflexes compared with the number evoked by distilled water. The intervalbetween the reflexes evoked by the agonists was shorter than that produced by distilled water. Prior topical application of respective TRPV1 or TRPM8 antagonists significantly reduced the number of agonist-evoked reflexes. The findings suggest that the activation of TRPV1 and TRPM8 channels present in the swallowing-related regions can facilitate the evoking of swallowing reflex. Targeting the TRP channels could be a potential therapeutic strategy for the management of dysphagia. |
| 書誌情報 |
en : International journal of molecular sciences.
巻 19,
号 12,
p. E4113,
発行日 2018-12-17
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| 出版者 |
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出版者 |
MDPI |
| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1422-0067 |
| PubMed番号 |
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関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
PMID |
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関連識別子 |
30567389 |
| DOI |
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|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.3390/ijms19124113 |
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関連名称 |
info:doi/10.3390/ijms19124113. |
| 権利 |
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|
権利情報 |
© 2018 by the authors. |
| 関連サイト |
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|
識別子タイプ |
URI |
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|
関連識別子 |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321618/ |
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|
関連名称 |
PubMed Central |
| フォーマット |
|
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内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
本文 (4.4 MB)
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