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  1. 学位論文
  2. 2021

Contribution of transglutaminases and their substrate proteins to the formation of cornified cell envelope in oral mucosal epithelium

https://mdu.repo.nii.ac.jp/records/3005
https://mdu.repo.nii.ac.jp/records/3005
b7db80ef-e810-4c69-99e3-f0bfe939e59e
名前 / ファイル ライセンス アクション
33602_A000282_shinsa-yoshi.pdf 内容の要旨および審査の結果の要旨 (2.5 MB)
license.icon
33602_A000282_honbun.pdf 本文 (1.3 MB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2022-06-20
タイトル
言語 en
タイトル Contribution of transglutaminases and their substrate proteins to the formation of cornified cell envelope in oral mucosal epithelium
言語
言語 eng
キーワード
言語 en
主題Scheme Other
主題 cornified envelope
キーワード
言語 en
主題Scheme Other
主題 keratinized oral epithelium
キーワード
言語 en
主題Scheme Other
主題 non-keratinized oral epithelium
キーワード
言語 en
主題Scheme Other
主題 substrates
キーワード
言語 en
主題Scheme Other
主題 transglutaminase
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_db06
資源タイプ doctoral thesis
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
その他(別言語等)のタイトル
その他のタイトル 口腔粘膜上皮における角質化細胞エンベロープ形成へのトランスグルタミナーゼと基質たんぱく質の寄与
著者 Rita, Rani Roy

× Rita, Rani Roy

WEKO 5553

Rita, Rani Roy

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Katsumitsu, Shimada

× Katsumitsu, Shimada

WEKO 5554

Katsumitsu, Shimada

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Satoshi, Murakami

× Satoshi, Murakami

WEKO 5555

Satoshi, Murakami

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Hiromasa, Hasegawa

× Hiromasa, Hasegawa

WEKO 5556

Hiromasa, Hasegawa

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著者別名 Roy, Rita Rani

× Roy, Rita Rani

WEKO 5557

Roy, Rita Rani

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Shimada, Katsumi

× Shimada, Katsumi

WEKO 5558

Shimada, Katsumi

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Murakami, Satoshi

× Murakami, Satoshi

WEKO 5559

Murakami, Satoshi

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Hasegwa, Hiromasa

× Hasegwa, Hiromasa

WEKO 5560

Hasegwa, Hiromasa

Search repository
抄録
内容記述タイプ Abstract
内容記述 Cornified envelope formation is crucial for the final differentiation of keratinized epithelium.However,the mechanisms of cornified envelope formation in the oral epithelium remain unclear.The aim of this study was to clarify the differences in the distribution and expression of cornified envelope related proteins and genes between keratinized and non-keratinized oral epithelia.We immunohistochemically investigated the distribution patterns of transglutaminase1(TG1),transglutaminase3(TG3),and their substrate proteins involucrin(IVL),loricrin(LOR),and small pro[1]line rich proteins(SPRs),in 19 keratinized and 14 non-keratinized oral epithelium samples.TG1 and TG3 mRNA levels were investigated in both types of epithelium by real time reverse transcription polymerase chain reaction(RT-PCR)using paraf[1]fin-embedded specimens.Data were analyzed to identify factors involved in cornified envelope formation.We demonstrate that 11 localization patterns show statistically significant differences between keratinized and non-keratinized oral epithelia.These factors clearly drove the separation of the two groups during cluster analysis.TG1 mRNA levels in keratinized oral epithelium were significantly higher than those in non-keratinized oral epithelium.In conclusion,the characteristic distribution of trans[1]glutaminases and their substrates and the mRNA levels of TG1 can regulate cornified envelope formation in keratinized oral epithelium, together with the contribution of TG3 first reported in this paper
書誌情報 en : European journal of oral sciences

巻 129, 号 1, p. e12760, 発行日 2021
情報源
関連名称 雑誌掲載論文(電子版)
ISSN
収録物識別子タイプ ISSN
収録物識別子 1600-0722
権利
権利情報 © 2021 European Journal of Oral Sciences
関連サイト
識別子タイプ URI
関連識別子 https://onlinelibrary.wiley.com/doi/full/10.1111/eos.12760
関連名称 Wiley Online Library
PubMed番号
識別子タイプ PMID
関連識別子 33501693
フォーマット
内容記述タイプ Other
内容記述 application/pdf
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
学位授与年度
内容記述タイプ Other
内容記述 2021
報告番号
内容記述タイプ Other
内容記述 甲第246号
学位授与番号
学位授与番号 甲第246号
学位授与年月日
学位授与年月日 2022-01-31
学位名
学位名 博士(歯学)
学位授与大学
学位授与機関識別子Scheme kakenhi
学位授与機関識別子 33602
学位授与機関名 松本歯科大学
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