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Contribution of transglutaminases and their substrate proteins to the formation of cornified cell envelope in oral mucosal epithelium
https://mdu.repo.nii.ac.jp/records/3005
https://mdu.repo.nii.ac.jp/records/3005b7db80ef-e810-4c69-99e3-f0bfe939e59e
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
内容の要旨および審査の結果の要旨 (2.5 MB)
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本文 (1.3 MB)
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| Item type | 学位論文 / Thesis or Dissertation正(1) | |||||
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| 公開日 | 2022-06-20 | |||||
| タイトル | ||||||
| タイトル | Contribution of transglutaminases and their substrate proteins to the formation of cornified cell envelope in oral mucosal epithelium | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | cornified envelope | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | keratinized oral epithelium | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | non-keratinized oral epithelium | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | substrates | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | transglutaminase | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| その他（別言語等）のタイトル | ||||||
| その他のタイトル | 口腔粘膜上皮における角質化細胞エンベロープ形成へのトランスグルタミナーゼと基質たんぱく質の寄与 | |||||
| 著者 |
Rita, Rani Roy
× Rita, Rani Roy× Katsumitsu, Shimada× Satoshi, Murakami× Hiromasa, Hasegawa |
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| 著者別名 |
Roy, Rita Rani
× Roy, Rita Rani× Shimada, Katsumi× Murakami, Satoshi× Hasegwa, Hiromasa |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Cornified envelope formation is crucial for the final differentiation of keratinized epithelium.However,the mechanisms of cornified envelope formation in the oral epithelium remain unclear.The aim of this study was to clarify the differences in the distribution and expression of cornified envelope related proteins and genes between keratinized and non-keratinized oral epithelia.We immunohistochemically investigated the distribution patterns of transglutaminase1(TG1),transglutaminase3(TG3),and their substrate proteins involucrin(IVL),loricrin(LOR),and small pro[1]line rich proteins(SPRs),in 19 keratinized and 14 non-keratinized oral epithelium samples.TG1 and TG3 mRNA levels were investigated in both types of epithelium by real time reverse transcription polymerase chain reaction(RT-PCR)using paraf[1]fin-embedded specimens.Data were analyzed to identify factors involved in cornified envelope formation.We demonstrate that 11 localization patterns show statistically significant differences between keratinized and non-keratinized oral epithelia.These factors clearly drove the separation of the two groups during cluster analysis.TG1 mRNA levels in keratinized oral epithelium were significantly higher than those in non-keratinized oral epithelium.In conclusion,the characteristic distribution of trans[1]glutaminases and their substrates and the mRNA levels of TG1 can regulate cornified envelope formation in keratinized oral epithelium, together with the contribution of TG3 first reported in this paper | |||||
| 書誌情報 |
en : European journal of oral sciences 巻 129, 号 1, p. e12760, 発行日 2021 |
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| 情報源 | ||||||
| 関連名称 | 雑誌掲載論文（電子版） | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1600-0722 | |||||
| 権利 | ||||||
| 権利情報 | © 2021 European Journal of Oral Sciences | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://onlinelibrary.wiley.com/doi/full/10.1111/eos.12760 | |||||
| 関連名称 | Wiley Online Library | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 33501693 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 学位授与年度 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 2021 | |||||
| 報告番号 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 甲第246号 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲第246号 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2022-01-31 | |||||
| 学位名 | ||||||
| 学位名 | 博士（歯学） | |||||
| 学位授与大学 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 33602 | |||||
| 学位授与機関名 | 松本歯科大学 | |||||
