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Glutamatergic modulation of slow inward rectification in trigeminal primary sensory neurons
https://mdu.repo.nii.ac.jp/records/384
https://mdu.repo.nii.ac.jp/records/384b5e06ca4-5cf0-4567-9404-2e243c4afbff
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
matsumoto_shigaku_34-01-01.pdf (802.7 kB)
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| Item type | Journal Article(1) | |||||||
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| 公開日 | 2012-05-23 | |||||||
| タイトル | ||||||||
| タイトル | Glutamatergic modulation of slow inward rectification in trigeminal primary sensory neurons | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | Inward rectification | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | Mes V neurons | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | Resonance | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| その他（別言語等）のタイトル | ||||||||
| その他のタイトル | 三叉神経一次感覚ニューロンにおける内向き整流作用のグルタミン酸受容体依存性神経修飾機構 | |||||||
| 著者 |
TANAKA, SUSUMU
× TANAKA, SUSUMU
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| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | In the present study, we showed that activation of metabotropic glutamate receptors in rat mesencephalic trigminal (Mes V) neurons (which are important in the genesis and control of oral-motor activities) can modulate hyperpolarization-activated inward current (Ih). Whole-cell recordings were obtained from rat Mes V neurons, and I_h was induced by a hyperpolarizing current or voltage pulses. Application of ACPD, which is a group I and II mGluRs agonist, suppressed the voltage-and time-dependent voltage sag under current-clamp recording, and suppressed the steady-state inward current under voltage-clamp recording, suggesting that it inhibited I_h. Further investigation revealed that group II mGluRs activation and the release of intracellular Ca^<2+> mediated ACPD-in-duced inhibition of I_h. Additionally, low-frequency (<10Hz) resonant properties exhibited at membrane potentials ranging from resting potential to hyperpolarization were substantially reduced by ACPD, indicating that modulation of I_h by mGluRs activation induces substantial changes in the frequency preference with which neurons respond to synaptic inputs. | |||||||
| 書誌情報 |
松本歯学 巻 34, 号 1, p. 1-12, 発行日 2008-04-30 |
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| 出版者 | ||||||||
| 出版者 | 松本歯科大学学会 | |||||||
| ISSN | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 0385-1613 | |||||||
| 書誌レコードID | ||||||||
| 収録物識別子タイプ | NCID | |||||||
| 収録物識別子 | AN00232590 | |||||||
| フォーマット | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | application/pdf | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
