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アイテム
哺乳動物における味覚の情報変換機序
https://mdu.repo.nii.ac.jp/records/707
https://mdu.repo.nii.ac.jp/records/7070d54214d-85dd-4de8-9eca-8999dee9948c
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
matsumoto_shigaku_25-01-01.pdf (1.5 MB)
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| Item type | Journal Article(1) | |||||||
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| 公開日 | 2012-05-24 | |||||||
| タイトル | ||||||||
| タイトル | 哺乳動物における味覚の情報変換機序 | |||||||
| 言語 | ||||||||
| 言語 | jpn | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | 味覚 | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | 味細胞 | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | 情報変換機序 | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | 哺乳動物 | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| その他（別言語等）のタイトル | ||||||||
| その他のタイトル | Taste Transduction Mechanisms in Mammals | |||||||
| 著者 |
浅沼, 直和
× 浅沼, 直和
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| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | This review describes the recent progress in the understanding of mammalian taste transduction mechanisms. Electrophysiological and biochemical studies have shown that taste cells use a variety of mechanisms for transducing taste stimuli into neural signals. i) A salty taste is transduced by an influx of Na^+ or some other alkali metal ions either through amiloride-sensitive Na^+ channels in the apical membranes of taste cells or through other Na^+ channels in the basolateral plasma membranes. ii) A sour taste is partly transduced by an influx of H^+ through the same amiloride-sensitive Na^+ channels as used for salty taste transduction and by other unknown mechanisms, which may involve unidentified H^+-gated cation channels. iii) A bitter taste is transduced by the binding of bitter substances to specific receptors on the taste cell membranes, which are coupled to second messenger-producing systems. One of the second messengers involved is inositol 1, 4, 5-trisphosphate (IP_3); others may be cyclic AMP and/or cyclic GMP. iv) A sweet taste is transduced, like the bitter taste, by the binding of sweet substances to the receptors coupled to systems producing second messengers such as cyclic AMP (or cyclic GMP) and IP_3. In some animals, sweet stimuli may cause an influx of external Na^+ by opening amiloride-sen-sitive Na^+ channels. A taste tissue-specific G protein α-subunit, α-gustducin, is believed to be involved in the transduction of both bitter and sweet tastes, the mechanism of which is yet to be elucidated. Bitter or sweet tasting amphiphilic molecules may penetrate taste cells and affect taste transduction systems directly from inside the cells. v) The transduction mechanism of 'umami' taste is not yet well understood, but a novel taste tissue-specific metabotropic glutamate receptor, mGluR4, is assumed to be working as a receptor for the taste of glutamate. | |||||||
| 書誌情報 |
松本歯学 巻 25, 号 1, p. 1-20, 発行日 1999-04-30 |
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| 出版者 | ||||||||
| 出版者 | 松本歯科大学学会 | |||||||
| ISSN | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 0385-1613 | |||||||
| 書誌レコードID | ||||||||
| 収録物識別子タイプ | NCID | |||||||
| 収録物識別子 | AN00232590 | |||||||
| フォーマット | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | application/pdf | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
