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有害金属拮抗薬DMSAおよびDMPSによるヒ素の排泄効果 : ラットとマウスの比較
https://mdu.repo.nii.ac.jp/records/983
https://mdu.repo.nii.ac.jp/records/9837ce4eb2f-240d-414e-b737-6cfbc6b6746c
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
matsumoto_shigaku_19-01-07.pdf (315.6 kB)
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| Item type | Journal Article(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| 公開日 | 2012-05-24 | |||||||
| タイトル | ||||||||
| タイトル | 有害金属拮抗薬DMSAおよびDMPSによるヒ素の排泄効果 : ラットとマウスの比較 | |||||||
| 言語 | ||||||||
| 言語 | jpn | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | 有害金属拮抗薬 | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | ラット | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | マウス | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | DMSA | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | DMPS | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| その他（別言語等）のタイトル | ||||||||
| その他のタイトル | Treatment of Arsenic Poisoning with DMSA or DMPS in the Rat | |||||||
| 著者 |
前橋, 浩
× 前橋, 浩
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| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Among many metal binding agents, 2, 3-dimercaptosuccinic acid (DMSA) and 2, 3 -dimercapto-1-propanesulfonic acid (DMPS) have been reported as effective antagonists against toxicity of several metals including arsenic. Rats appear to have a metabolic pathway different from that of mice in detoxicating arsenic in that rats accumulate arsenic in the blood (erythrocytes). Two experiments were carried out in order to determine the effects of DMSA and DMPS on the arsenic poisoned rats and to compare the results obtained with those of mice. In the first experiment, using arsenic poisoned rats, both DMSA and DMPS promoted the excretion of arsenic, in contrast to the results of mice previously reported in which those antidotes only accelerated the excretion of arsenic (Table 1). In the second experiment, both groups of rats and mice were given mixture of arsenic and DMSA or DMPS, respectively. The results showed that in mice 100% of dosed arsenic was excreted by DMPS within 48 hrs, while in rats 82% of the dose was eliminated by DMPS and about 20 % still remained within some of the tissues after 72 hrs (Tables 2, 3 and 4). | |||||||
| 書誌情報 |
松本歯学 巻 19, 号 1, p. 40-44, 発行日 1993-04-30 |
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| 出版者 | ||||||||
| 出版者 | 松本歯科大学学会 | |||||||
| ISSN | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 0385-1613 | |||||||
| 書誌レコードID | ||||||||
| 収録物識別子タイプ | NCID | |||||||
| 収録物識別子 | AN00232590 | |||||||
| フォーマット | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | application/pdf | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
